Microtomes Has Become An Important Precision Cutting Tool With Primary Applications In Plastic Embedded Tissues And Section Paraffin

Microtomes are an instrument used to create very small, thin slices of light-colored material called sections. Important in science, microtomes have been used in microscopes, enabling the examination of minute samples under an electron or light radiation. Microtomes are available in many designs, each with its own specialty, function, or application. For instance, there are segmented models that can be used for detailed imaging of animals. There are models for use with nuclear medicine instruments to study cancer cells. And there are miniaturized versions for use in laboratories for detailed studies of physiology, cell culture, and other processes.

The most common applications of microtomes are for research in the field of medicine and biology. Microtomes and other miniaturizing instruments are also used extensively in the field of microbiology, particularly in the diagnosis and treatment of diseases like Lyme disease. Microtomes and other instruments are also useful in the field of astronomy. Several applications in astronomy have developed because of their miniature size and capabilities.

Microtomes and other miniaturizing instruments have made great advances since their first application to medical science in the late 19th century. Originally, microtomes had simple sample preparation applications that included hooking a probe to a slide or petri dish and gathering sample points by gently nudging the device through the sample. The first applications of microtomes or other instruments were based on the principle of total internal reflection (TIR), which involves the collection of light from a sample or area in order to obtain quantitative data on the density and shape of that particular sample. TIR is useful in standardizing samples as it provides a more consistent picture of density and shape across the interior surface of the sample.